For an oocyte being Completely ready for fertilization and growth into an embryo, the best list of genes needs to be turned on. Namekawa suspected this pre-programming with the oocyte genome comes about in many phases — the initial a single starting up within the time a female is born. He believed that chromatin remodeling proteins did A great deal of this operate, by shifting spools close to.
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“We don’t know the way these cells are taken care of for many years,” suggests Namekawa. “We want to know The trick of the mechanism.
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At this stage, the mobile’s DNA is packaged having a matrix of specialised proteins – leaving it primed to the essential moment, a long time later on, when the egg is fertilized and commences developing into an embryo.
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